Preparation and in Vitro Evaluation of Tetrahydropalmatine Monolayer Osmotic Pump Tablets

In order to improve the biodiversity of the insoluble drug tetrahydropalmatine (THP), solid dispersion technology was used to improve the solubility of THP, and the effervescent technology was used for the osmotic pump to provide drug release power. The integrated use of osmotic pump technology was used to prepare tetrahydropalmatine monolayer osmotic pump tablets (THP osmotic pump tablets). The single factor experiment was performed to obtain the best prescription technique, and the in vitro release curve of the best prescription was modeled. The results showed that the type of suspending agent, the type and amount of porogen, the weight of coating and the release pore size affect the release behaviour of THP osmotic pump tablets greatly, however, the amount of plasticizer and the speed of propeller had no significant effects on the release behaviour of THP osmotic pump tablets. There were obvious zero-order release characteristics of the THP osmotic pump tablets prepared by best prescription process, r=0.9947, which meet with the requirements of controlled release preparation. The conclusion can be drawn that the production method of THP osmotic pump tablets is safe and reliable, simple and suitable for industrial production, and the method provides new ideas and research stratdgy for the preparation of other insoluble drug osmotic pump tablets.