Abstract: Teaching quality appraisal model based on multivariate statistical-neural network was proposed and was accomplished in Matlab, in which the relativity analytical technology and principle components analysis were used to appraisal and pre-handle analysis the influence factors, and BP neural network model was used for forecasting. The results indicated that the model based on multivariate statistical-BP neural network can avoid subjective impact of human and gained recognized conclusion. So, the model has broad applicability.