Abstract: In the report， in order to prevent invasive insect red fire ant （Solenopsis invicta Buren） and obtain the efficient chemical agents suitable for Hainan， the spraying method was used for chemical application， and the ham sausage trapping method was used to investigate the control effects. The results suggested that the efficient rate of indoxacarb and abamectin baits were all more than 90% for worker ants， live ant nests， the efficient rate of avermectins （3% and 5%） attain 100%. Among the tested chemical agents， the effects of indoxacarb bait are fast and good lasting， while that of the abamectin bait is slow. These findings suggested that indoxacarb and abamectin nano-poisonous baits can effectively control the red fire ant.