Abstract: In this paper, the serum apoprotein AI、B₁₀₀ and lipid are analysed in thirty one cases of liver cancer, thirty cases of liver cirrhosis and thirty one cases of chronic hepatitis, and they are compared with the ones resulted from 63 healthy adults. The results show that the total serum cholesterol, cholesterol in high density lipid protein and apoprotein AI in the group of patients decrease significantly, and the difference is statistically significant (P＜0.001). The serum triglyceride decreases in liver cancer patients and cirrhosis patients (P＜0.01 and P＜0.05). The serum apoprotein B₁₀₀ also decreases significantly (P＜0.001) in cirrhosis patients. The results indicate that measurement of serum lipid, apoprotein AI and B₁₀₀ may be useful in estimating the magnitude of liver damage.